Fig. 1 · Structure
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P62-RNF168 agonist-1
P62-RNF168 Agonist
P62-RNF168 agonist-1 is a potent agonist that enhances the interaction between P62 and RNF168, thereby modulating their biological activity. This compound is characterized by low cytotoxicity and effectively reduces H2A ubiquitination mediated by RNF168, disrupting homologous recombination-mediated DNA repair processes. Additionally, P62-RNF168 agonist-1 demonstrates significant efficacy in inhibiting the growth of xenograft tumors in mouse models in a dose-dependent manner, making it a valuable tool for cancer research and studies on DNA repair mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 2765180-17-2 |
| Applications | P62-RNF168 Agonist |
| Formula | C19H19N7O3 |
| Molecular Weight | 393.40 |
| SMILES | NC1=C2C(C=CC(C3=CN(C4=CC(OC)=C(C(OC)=C4)OC)N=N3)=C2)=NC(N)=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.