Fig. 1 · Structure
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PA-915
PAC1R Antagonist
PA-915 is a selective antagonist of the PAC1 receptor, prominently inhibiting the actions of pituitary adenylate cyclase-activating polypeptide (PACAP). This compound demonstrates significant potency in ameliorating PACAP and nerve injury-induced allodynia, making it valuable in research focused on pain modulation and neurobiology. Its oral bioactivity enhances its utility in pharmacological studies investigating PAC1 receptor-related pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 2305204-24-2 |
| Applications | PAC1R Antagonist |
| Formula | C17H17ClN6O2 |
| Molecular Weight | 372.81 |
| Synonyms | PAC1R antagonist 1 |
| SMILES | O=C(C1CC(N(C1)C2=NNC3=C2C=CC=C3Cl)=O)NCCC4=CNC=N4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.