Fig. 1 · Structure
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Pabinafusp alfa
Anti-Transferrin Receptor Antibody
Pabinafusp alfa is an anti-transferrin receptor antibody that targets the transferrin receptor and consists of Iduronate 2-sulfatase fused with an anti-human transferrin receptor antibody. This compound demonstrates blood-brain barrier permeability, effectively preventing heparan sulfate deposition within the central nervous system in models of mucopolysaccharidosis II (MPS II). Research indicates that Pabinafusp alfa enhances cognitive function and protects against neuronal damage in murine models, making it a promising candidate for studies related to lysosomal storage disorders and neuroprotection.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2140211-48-7 |
| Applications | Anti-Transferrin Receptor Antibody |
| Molecular Weight | 265.16 kDa |
| Synonyms | JR-141 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.