Fig. 1 · Structure
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Paclitaxel octadecanedioate
Anti-tumor Agent
Paclitaxel octadecanedioate is an anti-tumor agent formed by the conjugation of Paclitaxel to 1,18-octadecanedioic acid. This compound exhibits significant cytotoxicity against various cancer cell lines, including HT-1080, PANC-1, HT-29, and HeLa, with IC50 values of 12 nM, 2.48 nM, 8.62 nM, and 64.42 nM, respectively. Its formulation with human serum albumin enhances its potential for targeted cancer therapy applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2089211-45-8 |
| Applications | Anti-tumor Agent |
| Formula | C65H83NO17 |
| Molecular Weight | 1150.35 |
| SMILES | CC(O[C@]12[C@@]3([H])[C@@H]([C@]4(C(C)(C([C@H](C([C@@]3([C@H](C[C@@]1([H])OC2)O)C)=O)OC(C)=O)=C([C@H](C4)OC([C@H](OC(CCCCCCCCCCCCCCCCC(O)=O)=O)[C@H](C5=CC=CC=C5)NC(C6=CC=CC=C6)=O)=O)C)C)O)OC(C7=CC=CC=C7)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.