Fig. 1 · Structure
Documents & Downloads
PACMA 31
Protein Disulfide Isomerase Inhibitor
PACMA 31 is an irreversible inhibitor of protein disulfide isomerase (PDI) that demonstrates an IC50 of 10 μM. By forming covalent bonds with the active site cysteines of PDI, PACMA 31 effectively suppresses ovarian tumor growth while preserving the integrity of normal tissues. Additionally, PACMA 31 serves as a versatile click chemistry reagent, featuring an alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, making it suitable for various biochemical applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1401089-31-3 |
| Applications | Protein Disulfide Isomerase Inhibitor |
| Formula | C21H22N2O6S |
| Molecular Weight | 430.47 |
| SMILES | COC1=CC=C(N(C(C2=CC=CS2)C(NCC(OCC)=O)=O)C(C#C)=O)C(OC)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.