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Paeoniflorin-6′-O-benzene sulfonate

GRK2 Inhibitor

Paeoniflorin-6′-O-benzene sulfonate is a selective inhibitor of G protein-coupled receptor kinase 2 (GRK2), preventing its translocation to the cell membrane. This compound effectively inhibits the JAK1/STAT3 signaling pathway and mitigates IL-17A/CXCL2-induced proliferation in HaCaT cells. Furthermore, Paeoniflorin-6′-O-benzene sulfonate significantly reduces the levels of various inflammatory cytokines and chemokines, such as IL-17A, TNF-α, and CXCL2, demonstrating its potential in alleviating psoriasis in a mouse model. This reagent is valuable for research related to inflammatory diseases and signaling pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1390658-79-3
Applications	GRK2 Inhibitor
Formula	C₂₉H₃₂O₁₃S
Molecular Weight	620.62
Synonyms	CP-25
SMILES	O=C(C1=CC=CC=C1)OC[C@@]23[C@]4([C@]5(O[C@]2([H])O[C@@]([C@]3([H])C4)(C5)O)C)O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)COS(=O)(C7=CC=CC=C7)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.