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Palbociclib-C4-Boc

Target Protein Ligand-Linker Conjugate

Palbociclib-C4-Boc is a Target Protein Ligand-Linker Conjugate that combines the CDK4/6 inhibitor Palbociclib with a PROTAC linker to facilitate E3 ligase recruitment. This compound is instrumental in synthesizing PROTAC BSJ-03-204, allowing for targeted protein degradation studies. It is particularly valuable in cancer research where modulation of cell cycle proteins is essential for therapeutic intervention.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2139329-48-7
Applications	Target Protein Ligand-Linker Conjugate
Formula	C₃₃H₄₆N₈O₄
Molecular Weight	618.77
SMILES	O=C1N(C2CCCC2)C3=NC(NC4=CC=C(N(CC5)CCN5CCCCNC(OC(C)(C)C)=O)C=N4)=NC=C3C(C)=C1C(C)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.