Fig. 1 · Structure
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Pamidronate disodium pentahydrate
Anti-Osteoporosis Agent
Pamidronate disodium pentahydrate is a second-generation nitrogen-containing bisphosphonate that functions as an anti-osteoporosis agent. It effectively inhibits bone loss by upregulating osteoprotegerin expression while downregulating RANKL, MMP-9, and TLR-4 in both cartilage and subchondral bone, thus mitigating cartilage degeneration in early osteoarthritis. Furthermore, this compound inhibits Wnt and β-catenin signaling pathways, making it valuable for research applications related to osteoporosis and osteosarcoma.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 109552-15-0 |
| Applications | Anti-Osteoporosis Agent |
| Formula | C3H19NNa2O12P2 |
| Molecular Weight | 369.11 |
| SMILES | OC(P(O)(O[Na])=O)(CCN)P(O)(O[Na])=O.O.O.O.O.O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.