Fig. 1 · Structure
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Pantothenate kinase-IN-2
Pantothenate Kinase Inhibitor
Pantothenate kinase-IN-2 is a potent inhibitor of pantothenate kinase, exhibiting IC50 values of 92 nM for PanK2, 70 nM for PanK1β, and 25 nM for PanK3. This compound specifically binds to the ATP-PanK3 complex, effectively blocking coenzyme A (CoA) biosynthesis. Its inhibitory action makes Pantothenate kinase-IN-2 a valuable tool for investigating pantothenate kinase-related neurodegenerative diseases and type 2 diabetes research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 902614-04-4 |
| Applications | Pantothenate Kinase Inhibitor |
| Formula | C21H21N5OS |
| Molecular Weight | 391.49 |
| SMILES | O=C(NC1=CC=CC(SC)=C1)CCC2=C(C)N3C(N=C2C)=C(C=CC=N4)C4=N3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.