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PAR-2-IN-2

PAR-2 Inhibitor

PAR-2-IN-2 is a selective inhibitor of protease-activated receptor 2 (PAR-2), exhibiting an IC50 of 10.79 μM against the PAR-2 peptide SLIGKV, while demonstrating a significantly higher IC50 of over 200 μM for Trypsin. This compound is valuable for studying PAR-2 signaling pathways and exploring its role in inflammatory responses and pain modulation. PAR-2-IN-2 serves as a critical tool for researchers investigating therapeutic targets in conditions associated with PAR-2 activation.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	313986-65-1
Applications	PAR-2 Inhibitor
Formula	C₂₅H₂₀F₃N₅O₂
Molecular Weight	479.45
SMILES	O=C(N1CCN(CC1)C(C2=CC=CC=C2)=O)C3=NN4C(N=C(C5=CC=CC=C5)C=C4C(F)(F)F)=C3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.