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PAR2 modulator-1

PAR2 Antagonist

PAR2 modulator-1 is a selective antagonist of protease-activated receptor type 2 (PAR2). It effectively inhibits the PAR2-dependent MAPK signaling pathway, demonstrating an IC50 value of 8.5 μM. This compound is valuable for research in inflammation, immunology, and neurological disorders, including chronic pain and asthma, by blocking the pain response induced by PAR2 agonists.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	2378159-28-3
Applications	PAR2 Antagonist
Formula	C₂₇H₄₁N₅O₅
Molecular Weight	515.64
SMILES	O=C(C1=CC=CO1)N2C3N(C([C@H](C2)NC(CC(C)C)=O)=O)[C@H](C(N(C3)CC4CCNCC4)=O)CC(C)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.