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PAR4 antagonist 1

Catalog No.: A63485
Protease-Activated Receptor 4 Antagonist
PAR4 Antagonist 1 is a potent antagonist of Protease-Activated Receptor 4 (PAR4), exhibiting an IC50 of 1.8 nM. It effectively inhibits γ-thrombin-activated PAR4 in platelet-rich plasma with an IC50 of 2 nM. This compound is suitable for research applications focused on antithrombotic mechanisms and the modulation of platelet activation pathways.
PAR4 antagonist 1 2173201-65-3 Protease-Activated Receptor 4 Antagonist
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPAR4 Antagonist 1 is a potent antagonist of Protease-Activated Receptor 4 (PAR4), exhibiting an IC50 of 1.8 nM. It effectively inhibits γ-thrombin-activated PAR4 in platelet-rich plasma with an IC50 of 2 nM. This compound is suitable for research applications focused on antithrombotic mechanisms and the modulation of platelet activation pathways.
Product Information
Catalog NumA63485
FormulaC26H21FN6O4S
Molecular Weight532.55
CAS Number2173201-65-3
SMILESCOC1=NC2=CC(C)=CC(C3=NC4=C(C5=C(C(F)=C4)O[C@H](C5)COC(NC6=CN=C(N=C6)C)=O)S3)=C2N=C1
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

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This equation is commonly abbreviated as: C1V1 = C2V2

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GPCR/G Protein > Protease-Activated Receptors (PAR)