Fig. 1 · Structure
Documents & Downloads
PARL-IN-1
PARL Inhibitor
PARL-IN-1 is a potent inhibitor of presenilin-associated rhomboid-like protein (PARL) with an IC50 value of 28 nM. By inhibiting PARL, this compound effectively activates the PINK1/Parkin signaling pathway, promoting PINK1/Parkin-dependent mitophagy. This makes PARL-IN-1 a valuable tool for research into mitochondrial dynamics and quality control mechanisms in cellular processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3034516-68-9 |
| Applications | PARL Inhibitor |
| Formula | C39H56N6O7 |
| Molecular Weight | 720.90 |
| SMILES | C[C@H](NC(C)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(C(NCCCCC1=CC=CC=C1)=O)=O)C)=O)CC(C)C)=O)CC2=CC=CC=C2)=O)C(C)C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.