Fig. 1 · Structure
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PARL-IN-2
PARL Inhibitor
PARL-IN-2 is a potent covalent inhibitor of the mitochondrial intramembrane protease PARL, exhibiting an EC50 value of 0.16 μM. This compound effectively activates the PINK1/Parkin pathway, enhancing PINK1/Parkin-dependent mitophagy. PARL-IN-2 is a valuable reagent for research focused on mitochondrial dynamics and neurodegenerative disease mechanisms related to mitophagy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3099681-58-7 |
| Applications | PARL Inhibitor |
| Formula | C22H23NO4 |
| Molecular Weight | 365.42 |
| SMILES | O=C(OCC1=CC=CC=C1)C2=CC=C(CN3C(C(CC)(CC)C3=O)=O)C=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.