PARP1-IN-20, a selective PARP1 inhibitor, exhibits a potent inhibitory effect with an IC50 of 4.62 nM. This compound demonstrates minimal PARP-Trapping activity compared to other known inhibitors, including a significant threshold of >100 μM in the MDA-MB-436 cell line. PARP1-IN-20 is suitable for research applications focused on cancer therapy and DNA damage repair mechanisms.
PARP1-IN-20, a selective PARP1 inhibitor, exhibits a potent inhibitory effect with an IC50 of 4.62 nM. This compound demonstrates minimal PARP-Trapping activity compared to other known inhibitors, including a significant threshold of >100 μM in the MDA-MB-436 cell line. PARP1-IN-20 is suitable for research applications focused on cancer therapy and DNA damage repair mechanisms.
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