Fig. 1 · Structure
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PARP1-IN-20
PARP1 Inhibitor
PARP1-IN-20, a selective PARP1 inhibitor, exhibits a potent inhibitory effect with an IC50 of 4.62 nM. This compound demonstrates minimal PARP-Trapping activity compared to other known inhibitors, including a significant threshold of >100 μM in the MDA-MB-436 cell line. PARP1-IN-20 is suitable for research applications focused on cancer therapy and DNA damage repair mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2659357-95-4 |
| Applications | PARP1 Inhibitor |
| Formula | C23H19BrN6O3S |
| Molecular Weight | 539.40 |
| SMILES | O=C(N)C1=C2C(NC(C3=CC=C(C(N4CCN(C(C5=CSC(Br)=N5)=O)CC4)=O)C=C3)=N2)=CC=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.