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PARP1-IN-53

PARP1 Inhibitor

PARP1-IN-53 is a potent PARP1 inhibitor with an IC50 of 0.1 nM, demonstrating high selectivity over PARP2, which has an IC50 of 23 nM. This quinazolinone derivative effectively interferes with the poly(ADP-ribose) polymerase 1 enzyme, making it a valuable compound for cancer research. Its specific action on PARP1 enables detailed studies into the mechanisms of DNA repair and cell survival in oncology.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3087853-45-7
Applications	PARP1 Inhibitor
Formula	C₂₂H₁₉N₅O₃
Molecular Weight	401.42
SMILES	O=C1NC(/C=C/C(N2CCN(C3=CC=C(C#N)C=C3)CC2)=O)=NC4=C(O)C=CC=C41

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.