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PARP7-IN-18

Catalog No.: A28993
PARP7 Inhibitor
PARP7-IN-18 is a potent selective inhibitor of PARP7, exhibiting an IC50 value of 0.11 nM. This compound demonstrates significant anticancer activity, making it a valuable tool for research applications focused on cancer biology and the therapeutic potential of targeting PARP7. Its favorable pharmacokinetic properties further enhance its utility in in vivo studies and drug development.
PARP7-IN-18 2819999-00-1 PARP7 Inhibitor
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPARP7-IN-18 is a potent selective inhibitor of PARP7, exhibiting an IC50 value of 0.11 nM. This compound demonstrates significant anticancer activity, making it a valuable tool for research applications focused on cancer biology and the therapeutic potential of targeting PARP7. Its favorable pharmacokinetic properties further enhance its utility in in vivo studies and drug development.
Product Information
Catalog NumA28993
FormulaC23H26ClF3N6O4
Molecular Weight542.94
CAS Number2819999-00-1
SMILESO=C1NN=CC(N2CC[C@H]2COCCC(N3C[C@H]4N(C5=C(OCC4)C=C(Cl)C=N5)CC3)=O)=C1C(F)(F)F
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Epigenetics > PARP
DNA Damage > PARP