Pasotuxizumab (BAY 2010112) is a bispecific T-cell engager (BiTE) targeting PSMA and CD3, designed for the study of metastatic castration-resistant prostate cancer (mCRPC). This antibody exhibits binding affinities with dissociation constants (K_D) of 9.4 nM for human CD3 and 47.0 nM for PSMA, facilitating its dual specificity. Pasotuxizumab is instrumental in engaging T-cells and directing them towards PSMA-expressing prostate cancer cells, making it a valuable tool for advanced prostate cancer research.
Pasotuxizumab (BAY 2010112) is a bispecific T-cell engager (BiTE) targeting PSMA and CD3, designed for the study of metastatic castration-resistant prostate cancer (mCRPC). This antibody exhibits binding affinities with dissociation constants (K_D) of 9.4 nM for human CD3 and 47.0 nM for PSMA, facilitating its dual specificity. Pasotuxizumab is instrumental in engaging T-cells and directing them towards PSMA-expressing prostate cancer cells, making it a valuable tool for advanced prostate cancer research.
Targets
KDs: 9.4 nM and 16.3 nM for human and cynomolgus monkey CD3.
KDs: 47.0 nM and 212.6 nM for human and cynomolgus monkey PSMA.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
Please check COA/MSDS for correct molecular weight.
Calculate the dilution required to prepare a stock solution.This equation is commonly abbreviated as: C1V1 = C2V2
Frequently Asked Questions
What are Biosimilar Antibodies?
Biosimilar antibodies are research-grade recombinant antibodies designed to closely resemble approved therapeutic antibodies in terms of amino acid sequence, structural characteristics, and biological activity. These antibodies are generated using recombinant expression technologies and retain the same variable regions as their corresponding reference therapeutics, thereby preserving target specificity and binding affinity. Owing to these properties, biosimilar antibodies serve as reliable and cost-effective research reagents for applications in drug discovery, pharmacological studies, and basic biomedical research.
Research-grade biosimilar antibodies have been successfully expressed and functionally validated against a wide range of widely studied targets. These antibodies can be directly utilized as positive control reagents in drug discovery programs, as well as reference tools for rapid verification of the biological functions of target proteins in biochemical and cellular assays.
