Target & Activity
KDs: 47.0 nM and 212.6 nM for human and cynomolgus monkey PSMA.
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Pasotuxizumab (BAY 2010112) is a bispecific T-cell engager (BiTE) targeting PSMA and CD3, designed for the study of metastatic castration-resistant prostate cancer (mCRPC). This antibody exhibits binding affinities with dissociation constants (K_D) of 9.4 nM for human CD3 and 47.0 nM for PSMA, facilitating its dual specificity. Pasotuxizumab is instrumental in engaging T-cells and directing them towards PSMA-expressing prostate cancer cells, making it a valuable tool for advanced prostate cancer research.
In Stock
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1442657-12-6 |
| Synonyms | BAY 2010112; AMG 212 |
Store lyophilized at -20°C, keep desiccated.
In lyophilized form, the antibody is stable for 36 months.
After reconstitution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.