Fig. 1 · Structure
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Paxilline
BK Channel Blocker
Paxilline is a potent blocker of the large-conductance calcium-activated potassium (BK) channels. This indole alkaloid mycotoxin, derived from Penicillium paxilli, also inhibits sarco/endoplasmic reticulum Ca2+-stimulated ATPase (SERCA) with varying IC50 values ranging from 5 μM to 50 μM across different SERCA isoforms. Paxilline demonstrates significant anticonvulsant and neuroprotective activities, as well as exhibiting antioxidant properties, making it a valuable tool in neurobiology and pharmacological research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Blocker |
| CAS Number | 57186-25-1 |
| Applications | BK Channel Blocker |
| Formula | C27H33NO4 |
| Molecular Weight | 435.56 |
| SMILES | O=C1[C@@H](C(C)(O)C)O[C@](CC2)([H])C([C@]([C@@]2(C)[C@]34C)(O)CC[C@@]3([H])CC5=C4NC6=C5C=CC=C6)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.