Pazopanib-13C,d3 hydrochloride is a stable isotope-labeled form of Pazopanib hydrochloride, featuring deuterium and carbon-13 isotopes. It acts as a multi-target inhibitor, primarily affecting VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms, with IC50 values of 10, 30, 47, 84, 74, 140, and 146 nM, respectively. This reagent is valuable for biochemical studies and metabolic tracing applications in cancer research and related fields, allowing for detailed investigation of dose-response relationships and pharmacokinetics.
Pazopanib-13C,d3 hydrochloride is a stable isotope-labeled form of Pazopanib hydrochloride, featuring deuterium and carbon-13 isotopes. It acts as a multi-target inhibitor, primarily affecting VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms, with IC50 values of 10, 30, 47, 84, 74, 140, and 146 nM, respectively. This reagent is valuable for biochemical studies and metabolic tracing applications in cancer research and related fields, allowing for detailed investigation of dose-response relationships and pharmacokinetics.
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