Fig. 1 · Structure
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Pazopanib-13C,d3 hydrochloride
Stable Isotope
Pazopanib-13C,d3 hydrochloride is a stable isotope-labeled form of Pazopanib hydrochloride, featuring deuterium and carbon-13 isotopes. It acts as a multi-target inhibitor, primarily affecting VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms, with IC50 values of 10, 30, 47, 84, 74, 140, and 146 nM, respectively. This reagent is valuable for biochemical studies and metabolic tracing applications in cancer research and related fields, allowing for detailed investigation of dose-response relationships and pharmacokinetics.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1261398-44-0 |
| Applications | Stable Isotope |
| Formula | C2013CH21D3ClN7O2S |
| Molecular Weight | 477.99 |
| Synonyms | GW786034-13C,d3 hydrochloride |
| SMILES | CC1=C2C(C=C(C=C2)N(C3=NC(NC4=CC(S(N)(=O)=O)=C(C=C4)C)=NC=C3)[13C]([2H])([2H])[2H])=NN1C.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.