Fig. 1 · Structure
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Pazopanib-13C,d3
Stable Isotope
Pazopanib-13C,d3 is a stable isotope-labeled form of Pazopanib, a potent multi-target inhibitor primarily affecting VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with respective IC50 values of 10, 30, 47, 84, 74, 140, and 146 nM. This isotope-labeled compound is valuable in pharmacokinetic studies and metabolic research applications, facilitating the exploration of drug metabolism and distribution in biological systems. Ideal for use in quantitative analysis and imaging studies, Pazopanib-13C,d3 enhances the understanding of tumor angiogenesis and targeted cancer therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1261734-88-6 |
| Applications | Stable Isotope |
| Formula | C2013CH20D3N7O2S |
| Molecular Weight | 441.53 |
| Synonyms | GW786034-13C,d3 |
| SMILES | CC1=C2C(C=C(C=C2)N(C3=NC(NC4=CC(S(N)(=O)=O)=C(C=C4)C)=NC=C3)[13C]([2H])([2H])[2H])=NN1C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.