Pazopanib-d6 is a deuterium-labeled analog of Pazopanib, a potent multi-target inhibitor of various receptor tyrosine kinases. With specific targets including VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms, Pazopanib demonstrates inhibition with IC50 values of 10, 30, 47, 84, 74, 140, and 146 nM, respectively. This stable isotope derivative is essential for pharmacokinetic studies, tracer studies, and other research applications involving mass spectrometry and metabolic tracing.
Pazopanib-d6 is a deuterium-labeled analog of Pazopanib, a potent multi-target inhibitor of various receptor tyrosine kinases. With specific targets including VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms, Pazopanib demonstrates inhibition with IC50 values of 10, 30, 47, 84, 74, 140, and 146 nM, respectively. This stable isotope derivative is essential for pharmacokinetic studies, tracer studies, and other research applications involving mass spectrometry and metabolic tracing.
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