PB1 is a potent intracellular disulfide-reducing agent, designed as a borane-protected analogue of TCEP (tris(2-carboxyethyl)phosphine). It offers several advantages, including excellent cell permeability, the ability to establish high intracellular concentration gradients, and chemical stability. PB1 promotes retinal ganglion cell survival following axotomy in vitro at nanomolar to picomolar concentrations, making it a valuable tool for neuroprotective research.
PB1 is a potent intracellular disulfide-reducing agent, designed as a borane-protected analogue of TCEP (tris(2-carboxyethyl)phosphine). It offers several advantages, including excellent cell permeability, the ability to establish high intracellular concentration gradients, and chemical stability. PB1 promotes retinal ganglion cell survival following axotomy in vitro at nanomolar to picomolar concentrations, making it a valuable tool for neuroprotective research.
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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