Fig. 1 · Structure
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PB2
TCEP Analogue
PB2 is a tris(2-carboxyethyl)phosphine (TCEP) analogue that enhances the survival of retinal ganglion cells (RGCs) following axotomy in vitro at nanomolar and picomolar concentrations. With significantly greater permeability than TCEP, PB2 acts as a potent reducing agent, exhibiting notable neuroprotective effects on RGCs. This compound is of interest in neurological research and potential therapeutic applications aimed at protecting neuronal cells.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 914940-24-2 |
| Applications | TCEP Analogue |
| Formula | C16H20BO2P |
| Molecular Weight | 286.11 |
| SMILES | [H-][B+3]([P](CCC(OC)=O)(C1=CC=CC=C1)C2=CC=CC=C2)([H-])[H-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.