Fig. 1 · Structure
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PBD dimer-2
PBD Dimer
PBD dimer-2 is a C8-linked pyrrolobenzodiazepine dimer that effectively cross-links DNA at the 5′-Pu-GA(T/A)TC-Py sequence across an additional base pair. Its primary mechanism involves inducing DNA cross-links, leading to disruptions in normal cellular processes. This compound is particularly useful as a cytotoxic payload in antibody-drug conjugates (ADCs) and supports research into cancer therapeutics and mechanisms of action.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 145325-57-1 |
| Applications | PBD Dimer |
| Formula | C31H36N4O6 |
| Molecular Weight | 560.64 |
| SMILES | O=C1C2=CC(OC)=C(OCCCCCOC3=C(C=C4C(N=C[C@@]5([H])N(CCC5)C4=O)=C3)OC)C=C2N=C[C@@]6([H])N1CCC6 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.