Documents & Downloads

PBD dimer-4

PBD Dimer

PBD dimer-4 is a C1-substituted PBD dimer that exhibits high DNA-binding affinity and significant DNA cross-linking capabilities. This compound demonstrates potent cytotoxicity against MDA-MB-231 breast cancer cells, with an IC50 value of 236 nM. PBD dimer-4 is utilized as a payload in antibody-drug conjugates, such as Loncastuximab tesirine, making it an important reagent for cancer research and therapeutic development.

Out of Stock

Free Aliquoting for Your Order

Tell us your preferred amount per vial. We’ll confirm the options.

Specifications

Manufacturer	Adooq Bioscience
CAS Number	1821339-88-1
Applications	PBD Dimer
Formula	C₃₁H₃₆N₄O₈
Molecular Weight	592.64
SMILES	[H][C@]12C=NC3=CC(OC)=C(C=C3C(N1CC[C@@H]2OCCCO[C@H]4CCN5C(C6=CC(OC)=C(C=C6N=C[C@]45[H])OC)=O)=O)OC

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.