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PBRM1/SMARCA2,4-ligand-1

Ligand for Target Protein for PROTAC

PBRM1/SMARCA2,4-ligand-1 is a ligand specifically designed for the targeted protein degradation approach via PROTAC technology. It binds selectively to the PBRM1, SMARCA2, and SMARCA4 proteins, serving as a potent SMARCA4 bromodomain inhibitor. This compound is suitable for use in the synthesis of the PROTAC AU-24118, facilitating research into targeted degradation mechanisms and therapeutic strategies in cancer biology.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	1997321-76-2
Applications	Ligand for Target Protein for PROTAC
Formula	C₁₆H₁₃N₃O
Molecular Weight	263.29
SMILES	NC1=C(C=C(N=N1)C2=C(C=CC=C2)O)C3=CC=CC=C3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.