PD 0332991 Isethionate

PD 0332991 Isethionate Chemical Structure

CAS NO. 827022-33-3

PD 0332991 Isethionate is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM respectively.

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10 mg

Regular Price: $70.00

Special Price $63.00

25 mg

Regular Price: $110.00

Special Price $99.00

50 mg

Regular Price: $140.00

Special Price $126.00

10mM * 1mL in DMSO

Regular Price: $60.00

Special Price $54.00

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Biological Activity

PD 0332991 Isethionate is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM respectively.
Targets
Target Value
CDK4/CyclinD3IC50: 9nM
CDK4/CyclinD1IC50: 11nM
CDK6/CyclinD2IC50: 15nM
CDK2/CyclinE2IC50: >10μM
CDK2/CyclinAIC50: >10μM
CDK1/CyclinBIC50: >10μM
CDK5/p25IC50: >10μM
EGFRIC50: >10μM
FGFRIC50: >10μM
PDGFRIC50: >10μM
Insulin ReceptorIC50: >10μM
VEGFRIC50: >10μM
AMPKIC50: >10μM
Chk1IC50: >10μM
c-SrcIC50: >10μM
GSK-3βIC50: >10μM
MAPK2/ERK2IC50: >10μM
MAPKKIC50: >10μM
p70S6KIC50: >10μM
PKBIC50: >10μM
PKCIC50: >10μM
In vitro (25°C) DMSO 50 mg/mL heating (87.15 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.66 mL 103.31 mL 206.62 mL
0.5 mM 4.13 mL 20.66 mL 41.32 mL
1 mM 2.07 mL 10.33 mL 20.66 mL
5 mM 0.41 mL 2.07 mL 4.13 mL

*The above data is based on the productmolecular weight 483.99. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13811
Actions Inhibitor
M. Wt 483.99
Formula C24H30ClN7O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 827022-33-3
Synonyms PD0332991, PD-0332991
SMILES CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C.C(CS(=O)(=O)O)O

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