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PD-1-IN-25

PD-1/PD-L1 Inhibitor

PD-1-IN-25 is a potent inhibitor of the PD-1/PD-L1 interaction, exhibiting an IC50 value of 10.2 nM as determined by HTRF assay. This compound enhances CD8+ T cell activation by disrupting PD-1/PD-L1 signaling pathways. PD-1-IN-25 demonstrates significant potential for delaying tumor growth, making it a valuable tool for cancer immunotherapy research.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2413100-40-8
Applications	PD-1/PD-L1 Inhibitor
Formula	C₃₇H₃₅ClF₂N₂O₉
Molecular Weight	725.13
SMILES	CC1=C(C=CC=C1C(F)(F)OC2=CC(OCC3=CC(C#N)=CC=C3)=C(C=C2Cl)CN[C@H]4[C@H]([C@@H]([C@H](OC4O)CO)O)O)C5=CC=C(OCCO6)C6=C5

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.