Fig. 1 · Structure
Documents & Downloads
PD-1/PD-L1-IN-13
PD-1/PD-L1 Interaction Inhibitor
PD-1/PD-L1-IN-13 is a potent inhibitor of the PD-1/PD-L1 interaction, exhibiting an IC50 value of 10.2 nM. This compound effectively promotes CD8+ T cell activation, enhancing anti-tumor immunity. Its application in preclinical models, such as the Hepa1-6 syngeneic mouse model, demonstrates its potential to delay tumor growth, making it valuable for research in immunotherapy and cancer biology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2865841-81-0 |
| Applications | PD-1/PD-L1 Interaction Inhibitor |
| Formula | C36H34ClF2N3O9 |
| Molecular Weight | 726.12 |
| SMILES | CC1=C(C=CC=C1C(F)(F)OC2=C(Cl)C=C(CN[C@@H]3C(O)O[C@H](CO)[C@@H](O)[C@@H]3O)C(OCC4=CC(C#N)=NC=C4)=C2)C5=CC=C(OCCO6)C6=C5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.