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PD-1/PD-L1-IN-18

PD-1/PD-L1 Inhibitor

PD-1/PD-L1-IN-18 is a small-molecule inhibitor that specifically targets the PD-1/PD-L1 protein-protein interaction, demonstrating an IC50 of 1.054 μM. This compound effectively blocks PD-1/PD-L1 signaling, facilitating enhanced T-cell activation and antitumor responses. It is valuable for research applications focused on immunotherapy and cancer treatment strategies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2648851-27-6
Applications	PD-1/PD-L1 Inhibitor
Formula	C₃₃H₃₂BrCl₂N₃O₄
Molecular Weight	685.43
SMILES	ClC1=C(OCC2=CC=CC(C3=CC=CC=C3)=C2Br)C=C(OCC4=CC5=NON=C5C=C4)C(CNC6CCC(CC6)O)=C1.Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.