Fig. 1 · Structure
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PD-1/PD-L1-IN-26
PD-1/PD-L1 Inhibitor
PD-1/PD-L1-IN-26 is a potent inhibitor of the programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) pathway, exhibiting an IC50 of 0.0380 μM. This compound enhances the immune microenvironment by facilitating the infiltration of CD4+ T cells into tumor tissues. PD-1/PD-L1-IN-26 is valuable for research applications focused on cancer immunotherapy and the modulation of immune responses in tumor biology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2966090-78-6 |
| Applications | PD-1/PD-L1 Inhibitor |
| Formula | C43H52N4O8 |
| Molecular Weight | 752.89 |
| SMILES | CC1=C(C=CC=C1C2=CC=CC(OCCCN3CCC(CC3)CO)=C2)COC4=CC=C(C(OCC5=NN=C(O5)C6=CC=CC=C6)=C4)CNC(CO)(CO)CO |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.