Fig. 1 · Structure
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PD-1/PD-L1-IN-29
PD-1/PD-L1 Inhibitor
PD-1/PD-L1-IN-29 is a potent inhibitor of the PD-1/PD-L1 pathway, exhibiting an IC50 value of 6.1 nM. This compound effectively binds to PD-L1 to disrupt PD-1/PD-L1 interactions, facilitating PD-L1 dimerization and subsequent internalization, while enhancing its localization to the endoplasmic reticulum. PD-1/PD-L1-IN-29 demonstrates significant anticancer activity, making it a valuable tool for research in immuno-oncology and therapeutic applications targeting immune checkpoint pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2665734-13-2 |
| Applications | PD-1/PD-L1 Inhibitor |
| Formula | C26H24N2O6 |
| Molecular Weight | 460.48 |
| SMILES | OC[C@H](NCC1=CC2=C(C=C1OC)C(N(C2=O)C3=C(C(C4=CC=CC=C4)=CC=C3)C)=O)C(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.