PD-1/PD-L1-IN-29 is a potent inhibitor of the PD-1/PD-L1 pathway, exhibiting an IC50 value of 6.1 nM. This compound effectively binds to PD-L1 to disrupt PD-1/PD-L1 interactions, facilitating PD-L1 dimerization and subsequent internalization, while enhancing its localization to the endoplasmic reticulum. PD-1/PD-L1-IN-29 demonstrates significant anticancer activity, making it a valuable tool for research in immuno-oncology and therapeutic applications targeting immune checkpoint pathways.
PD-1/PD-L1-IN-29 is a potent inhibitor of the PD-1/PD-L1 pathway, exhibiting an IC50 value of 6.1 nM. This compound effectively binds to PD-L1 to disrupt PD-1/PD-L1 interactions, facilitating PD-L1 dimerization and subsequent internalization, while enhancing its localization to the endoplasmic reticulum. PD-1/PD-L1-IN-29 demonstrates significant anticancer activity, making it a valuable tool for research in immuno-oncology and therapeutic applications targeting immune checkpoint pathways.
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