PD-1/PD-L1-IN-31

Catalog No.: A35741
PD-1/PD-L1 Inhibitor
PD-1/PD-L1-IN-31 is a potent inhibitor of the PD-1/PD-L1 pathway, demonstrating an IC50 value of 2.2 nM. This compound enhances the secretion of interferon-gamma (IFN-γ) and stimulates the immune response of peripheral blood mononuclear cells (PBMCs), leading to the inhibition of tumor cell proliferation. PD-1/PD-L1-IN-31 is valuable for research applications focused on cancer immunotherapy and the modulation of immune checkpoints.
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5mg
10mg
50mg
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Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPD-1/PD-L1-IN-31 is a potent inhibitor of the PD-1/PD-L1 pathway, demonstrating an IC50 value of 2.2 nM. This compound enhances the secretion of interferon-gamma (IFN-γ) and stimulates the immune response of peripheral blood mononuclear cells (PBMCs), leading to the inhibition of tumor cell proliferation. PD-1/PD-L1-IN-31 is valuable for research applications focused on cancer immunotherapy and the modulation of immune checkpoints.
Product Information
Catalog NumA35741
FormulaC24H24ClFN2O3
Molecular Weight442.91
CAS Number3049472-36-5
SMILESFC1=CC=CC=C1C2=CC=CC3=C2CC[C@@H]3OC4=NC(OC)=C(CNCCO)C=C4Cl
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