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PD-1/PD-L1-IN-32

PD-1/PD-L1 Inhibitor

PD-1/PD-L1-IN-32 is a potent inhibitor of the PD-1/PD-L1 pathway, exhibiting an IC50 of 2.4 nM. This compound demonstrates significant anticancer activity by effectively inhibiting tumor growth in a humanized mouse model expressing PD-L1. Importantly, PD-1/PD-L1-IN-32 exhibits limited toxicity on normal mouse tissues, making it a valuable tool for cancer research and therapeutic applications targeting immune checkpoint pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2765535-21-3
Applications	PD-1/PD-L1 Inhibitor
Formula	C₂₉H₂₅ClFN₃O₃
Molecular Weight	517.98
SMILES	N#CC1=CC(COC2=C(C=CC(OCC3=C(C(C4=CC=CC=C4F)=CC=C3)Cl)=C2)CNCCO)=CN=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.