Fig. 1 · Structure
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PD-1/PD-L1-IN-34
PD-1/PD-L1 Inhibitor
PD-1/PD-L1-IN-34 is a potent inhibitor of the PD-1/PD-L1 interaction, exhibiting an IC50 of 0.029 μM, and demonstrates a binding affinity towards PD-L1 with a KD of 0.1554 μM. This compound activates the immune microenvironment, showcasing significant anti-tumor activity which reinforces its potential in cancer immunotherapy research. PD-1/PD-L1-IN-34 is an invaluable tool for elucidating mechanisms of immune modulation and evaluating therapeutic strategies in oncology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2924403-17-6 |
| Applications | PD-1/PD-L1 Inhibitor |
| Formula | C35H33ClN2O3 |
| Molecular Weight | 565.10 |
| SMILES | CC1=C([C@@H]2[C@@H](C3=CC(OCC4=CC=CC(C#N)=C4)=C(C=C3Cl)CNC(C)(C(O)=O)C)C2)C=CC=C1C5=CC=CC=C5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.