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PD-1/PD-L1-IN-52

PD-1/PD-L1 Inhibitor

PD-1/PD-L1-IN-52 is an orally bioavailable inhibitor of the PD-1/PD-L1 interaction, demonstrating an IC50 of 109.9 nM. This compound exhibits significant antitumor effects, as evidenced by a tumor growth inhibition (TGI) of 49.6% in a C57BL/6 mouse xenograft model utilizing human PD-1-expressing MC38 colon cancer cells. Research applications include the exploration of immune checkpoint modulation and therapeutic strategies in cancer treatment.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2856391-46-1
Applications	PD-1/PD-L1 Inhibitor
Formula	C₄₅H₅₂ClN₇O₉
Molecular Weight	870.39
SMILES	OC[C@H](C(OCC)=O)NCC1=CC(Cl)=C(OCC2=C(C)C(C3=CC=CC(OCCCN4N=NC(CN[C@@H](C(OCC)=O)CO)=C4)=C3C)=CC=C2)C=C1OCC5=CC(C#N)=CN=C5

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.