PD-1/PD-L1-IN 6 is a potent inhibitor of the PD-1/PD-L1 interaction, demonstrating an IC50 value of 132.8 nM. This compound exhibits significant immunoregulatory activity, notably enhancing interferon-γ secretion in a Hep3B/OS-8/hPD-L1 and CD3 T cell co-culture model, while exhibiting minimal toxicity. Additionally, PD-1/PD-L1-IN 6 is effective in restoring immune responses in T cell-tumor co-culture models, making it a valuable reagent for immunotherapy research and studies related to cancer immunology.
PD-1/PD-L1-IN 6 is a potent inhibitor of the PD-1/PD-L1 interaction, demonstrating an IC50 value of 132.8 nM. This compound exhibits significant immunoregulatory activity, notably enhancing interferon-γ secretion in a Hep3B/OS-8/hPD-L1 and CD3 T cell co-culture model, while exhibiting minimal toxicity. Additionally, PD-1/PD-L1-IN 6 is effective in restoring immune responses in T cell-tumor co-culture models, making it a valuable reagent for immunotherapy research and studies related to cancer immunology.
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