Fig. 1 · Structure
Documents & Downloads
PD-1/PD-L1-IN 6
PD-1/PD-L1 inhibitor
PD-1/PD-L1-IN 6 is a potent inhibitor of the PD-1/PD-L1 interaction, demonstrating an IC50 value of 132.8 nM. This compound exhibits significant immunoregulatory activity, notably enhancing interferon-γ secretion in a Hep3B/OS-8/hPD-L1 and CD3 T cell co-culture model, while exhibiting minimal toxicity. Additionally, PD-1/PD-L1-IN 6 is effective in restoring immune responses in T cell-tumor co-culture models, making it a valuable reagent for immunotherapy research and studies related to cancer immunology.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2393983-76-9 |
| Applications | PD-1/PD-L1 inhibitor |
| Formula | C25H26N2O3 |
| Molecular Weight | 402.49 |
| SMILES | O=C(C1=CC=C(CNCCO)C(OC)=C1)N2CCC3=C2C=CC=C3C4=CC=CC=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.