Fig. 1 · Structure
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PD 118717
D-2 Autoreceptor Agonist
PD 118717 is a selective agonist of the D-2 dopamine autoreceptor, demonstrating significant affinity for the 5-HT1A receptor while showing minimal interaction with 5-HT1B and 5-HT2 receptors. This compound effectively antagonizes the tau-butyrolactone-induced accumulation of dopamine in the rat striatum and mesolimbic regions. PD 118717 is utilized in research related to antipsychotic treatments, providing insights into neuropharmacological profiles associated with dopaminergic modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 104229-37-0 |
| Applications | D-2 Autoreceptor Agonist |
| Formula | C20H22N4O3 |
| Molecular Weight | 366.41 |
| SMILES | O=C1C=CC2=CC=C(OCCCN3CCN(C4=NC=CC=N4)CC3)C=C2O1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.