Fig. 1 · Structure
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PD 121373
DNA Complexing Agent
PD 121373 is a potent DNA complexing agent that exhibits significant antitumor activity. It effectively binds to DNA and RNA, subsequently inhibiting their synthesis, with reported IC50 values of 0.5 μM for DNA and 0.3 μM for RNA in L1210 cells. This compound is valuable for research applications focused on understanding mechanisms of nucleic acid synthesis inhibition and exploring potential therapeutic strategies in cancer treatment.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 113457-06-0 |
| Applications | DNA Complexing Agent |
| Formula | C21H27N5OS |
| Molecular Weight | 397.54 |
| SMILES | OC1=CC2=C(SC3=C(NCCN)C=CC4=C3C2=NN4CCN(CC)CC)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.