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PD 140376

CholecystokininB/gastrin Receptor Antagonist

PD 140376 is a highly potent antagonist of the cholecystokinin B/gastrin receptor, exhibiting Ki values of 0.18 nM in guinea pig cortex and 0.21 nM in gastric gland membranes. This compound is valuable for investigating the physiological role of cholecystokinin and gastrin in various biological processes. Its use extends to research applications focusing on gastrointestinal function and receptor signaling pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	149027-97-4
Applications	CholecystokininB/gastrin Receptor Antagonist
Formula	C₃₃H₄₀N₄O₅
Molecular Weight	572.69
SMILES	O=C(C[C@H](CC1=CC=C(C=C1)N)NC([C@@](C)(CC2=CNC3=C2C=CC=C3)NC(OC4C5CC(CC4C6)CC6C5)=O)=O)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.