PD-L1-IN-3 is a PD-L1 inhibitor that effectively targets the PD-1/PD-L1 interaction. With an IC50 value of 4.97 nM for inhibiting PD-L1 and an EC50 value of 2.70 μM for Jurkat T cell activation, this compound disrupts PD-1 signaling by binding to the PD-L1 dimer. PD-L1-IN-3 is particularly valuable for research applications in lung cancer and melanoma, facilitating the study of immune checkpoint mechanisms in these diseases.
PD-L1-IN-3 is a PD-L1 inhibitor that effectively targets the PD-1/PD-L1 interaction. With an IC50 value of 4.97 nM for inhibiting PD-L1 and an EC50 value of 2.70 μM for Jurkat T cell activation, this compound disrupts PD-1 signaling by binding to the PD-L1 dimer. PD-L1-IN-3 is particularly valuable for research applications in lung cancer and melanoma, facilitating the study of immune checkpoint mechanisms in these diseases.
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