PD-L1-IN-4

Catalog No.: A35759
PD-L1 Inhibitor
PD-L1-IN-4 is a selective inhibitor of PD-L1, demonstrating potent inhibition of the PD-1/PD-L1 interaction with an IC50 value of 1.3 nM. This compound also enhances the PD-L1 inhibitory effect on T cells, with an EC50 of 152.8 nM. PD-L1-IN-4 is suitable for studies in cancer research, particularly in the context of immunotherapy and tumor microenvironment modulation.
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Size Stock
5mg
10mg
50mg
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Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPD-L1-IN-4 is a selective inhibitor of PD-L1, demonstrating potent inhibition of the PD-1/PD-L1 interaction with an IC50 value of 1.3 nM. This compound also enhances the PD-L1 inhibitory effect on T cells, with an EC50 of 152.8 nM. PD-L1-IN-4 is suitable for studies in cancer research, particularly in the context of immunotherapy and tumor microenvironment modulation.
Product Information
Catalog NumA35759
FormulaC38H40ClFN4O8
Molecular Weight735.20
CAS Number2597056-86-3
SMILESFC1=C(C=CC=C1C2=CC(OCCCN3CCC(CC3)O)=CC=C2)COC4=CC(OCC5=CC6=NON=C6C=C5)=C(C=C4Cl)CN[C@@H](C(O)=O)CO
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