PD-L1-IN-7 is a potent inhibitor of programmed cell death ligand 1 (PD-L1), effectively disrupting the PD-1/PD-L1 interaction with an IC50 of 0.2 nM. This compound facilitates the internalization and retention of PD-L1 within cells, alters glycosylation patterns, and promotes PD-L1 degradation. PD-L1-IN-7 enhances T cell infiltration and boosts T cell cytotoxic function, making it a valuable tool for developing immunotherapeutic strategies against tumors.
PD-L1-IN-7 is a potent inhibitor of programmed cell death ligand 1 (PD-L1), effectively disrupting the PD-1/PD-L1 interaction with an IC50 of 0.2 nM. This compound facilitates the internalization and retention of PD-L1 within cells, alters glycosylation patterns, and promotes PD-L1 degradation. PD-L1-IN-7 enhances T cell infiltration and boosts T cell cytotoxic function, making it a valuable tool for developing immunotherapeutic strategies against tumors.
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