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PD-L1-IN-8

PD-L1 Inhibitor

PD-L1-IN-8 is a selective PD-L1 inhibitor with an IC50 of 0.89 nM. It demonstrates low inhibition of cytochrome P450 enzymes and minimal hERG activity, indicating a favorable safety profile. This compound is specifically useful in the investigation of PD-L1 mediated immune evasion in colon cancer research, contributing to the understanding of tumor-immune system interactions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3104751-99-4
Applications	PD-L1 Inhibitor
Formula	C₄₀H₄₂ClN₉O₃
Molecular Weight	732.27
SMILES	ClC(C(NC1=NC=CC2=C1N=CC(CN3CC[C@@H](O)C3)=C2)=CC=C4)=C4C5=CC=CC6=C5CCN6C(C7=NN(CCCC8NC[C@@H]9CCC(N9)=O)C8=C7)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.