PD-L1/VISTA-IN-1 is a potent dual-target inhibitor of programmed death ligand 1 (PD-L1) and V-domain Ig suppressor of T cell activation (VISTA). This compound effectively disrupts the PD-1/PD-L1 interaction with an IC50 of 0.1492 μM and inhibits the VISTA pathway with a KD of 0.2723 μM, promoting T cell reactivation. PD-L1/VISTA-IN-1 demonstrates significant anti-tumor activity, making it a valuable tool for cancer immunotherapy research.
PD-L1/VISTA-IN-1 is a potent dual-target inhibitor of programmed death ligand 1 (PD-L1) and V-domain Ig suppressor of T cell activation (VISTA). This compound effectively disrupts the PD-1/PD-L1 interaction with an IC50 of 0.1492 μM and inhibits the VISTA pathway with a KD of 0.2723 μM, promoting T cell reactivation. PD-L1/VISTA-IN-1 demonstrates significant anti-tumor activity, making it a valuable tool for cancer immunotherapy research.
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