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PD-L1/VISTA-IN-1

PD-L1/VISTA Inhibitor

PD-L1/VISTA-IN-1 is a potent dual-target inhibitor of programmed death ligand 1 (PD-L1) and V-domain Ig suppressor of T cell activation (VISTA). This compound effectively disrupts the PD-1/PD-L1 interaction with an IC50 of 0.1492 μM and inhibits the VISTA pathway with a KD of 0.2723 μM, promoting T cell reactivation. PD-L1/VISTA-IN-1 demonstrates significant anti-tumor activity, making it a valuable tool for cancer immunotherapy research.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2978623-09-3
Applications	PD-L1/VISTA Inhibitor
Formula	C₂₂H₂₄N₄O₄
Molecular Weight	408.45
SMILES	CC1=C(C=CC=C1C2=CC=CC=C2)NC3=NC(OC)=CC(CN[C@H](C(O)=O)CO)=N3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.