PD-M6 is an mTOR-targeted PROTAC degrader that facilitates the ubiquitination and subsequent degradation of mTOR, exhibiting a DC50 of 4.8 μM. This compound has demonstrated potent anti-proliferative effects on HeLa, MCF-7, and HepG2 cancer cell lines, with IC50 values of 11.3, 2.58, and 3.23 μM, respectively. Additionally, PD-M6 induces autophagy and specifically promotes the degradation of LAMTOR1, a pivotal component of the mTOR signaling pathway, suggesting its utility for investigating mTOR-related biological processes in cancer research.
PD-M6 is an mTOR-targeted PROTAC degrader that facilitates the ubiquitination and subsequent degradation of mTOR, exhibiting a DC50 of 4.8 μM. This compound has demonstrated potent anti-proliferative effects on HeLa, MCF-7, and HepG2 cancer cell lines, with IC50 values of 11.3, 2.58, and 3.23 μM, respectively. Additionally, PD-M6 induces autophagy and specifically promotes the degradation of LAMTOR1, a pivotal component of the mTOR signaling pathway, suggesting its utility for investigating mTOR-related biological processes in cancer research.
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