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PD1-PDL1-IN-4

PD1-PDL1 Inhibitor

PD1-PDL1-IN-4 is a potent inhibitor of the PD1-PDL1 pathway, functioning primarily by modulating TIGIT and PD-1 signaling. This compound effectively enhances the proliferation of CD8+ T cells and mouse splenocytes, making it a valuable tool in immunological research. Additionally, PD1-PDL1-IN-4 has demonstrated efficacy in inhibiting tumor growth in a CT26 syngeneic colon adenocarcinoma mouse model, supporting its application in colon cancer studies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2007110-15-6
Applications	PD1-PDL1 Inhibitor
Formula	C₁₉H₂₅N₅O₆
Molecular Weight	419.43
SMILES	OC(C=C1)=CC=C1C[C@@H](C2=NC([C@@H](N)[C@@H](O)C)=NO2)NC(N3[C@@H](CCC3)C(O)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.