Fig. 1 · Structure
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PD130883
Antifolate
PD130883 is an antifolate compound that serves as a potent inhibitor of dihydrofolate reductase (DHFR). It targets the 5,10-methylenetetrahydrofolate binding site of thymidylate synthase, consequently decreasing the conversion of tetrahydrofolate cofactor to dihydrofolate. This mechanism is vital in research related to cancer treatment and the examination of folate metabolism pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 123685-36-9 |
| Applications | Antifolate |
| Formula | C18H15N5O3 |
| Molecular Weight | 349.34 |
| SMILES | O=C1NC(N)=NC2=C1C=C(C=C2)CN(CC#C)C3=CC=C(C=C3)[N+]([O-])=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.