Catalog No.: A12725

EGFR inhibitor


PD168393 Chemical Structure

CAS NO. 194423-15-9

PD168393 is a potent, cell-permeable, irreversible inhibitor of EGFR with IC50 value of 700 pM.

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Biological Activity

PD168393 is a potent, cell-permeable, irreversible inhibitor of EGFR with IC50 value of 700 pM.
EGFR Insulin Receptor PDGFR FGFR PKC
0.70 nM>50 μM>50 μM>50 μM>50 μM
In vitro (25°C) DMSO 72 mg/mL (195 mM)
Water Insoluble
Ethanol Insoluble
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.08 mL 135.42 mL 270.84 mL
0.5 mM 5.42 mL 27.08 mL 54.17 mL
1 mM 2.71 mL 13.54 mL 27.08 mL
5 mM 0.54 mL 2.71 mL 5.42 mL

*The above data is based on the productmolecular weight 369.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12725
Actions Inhibitor
CAS No. 194423-15-9
Formula C17H13BrN4O
M. Wt 369.22
Purity >98%
Synonyms PD-168393, PD 168393

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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